翻訳と辞書 Words near each other ・ Protein geranylgeranyltransferase type I ・ Protein geranylgeranyltransferase type II ・ Protein histidine kinase ・ Protein I-sites ・ Protein IB5 ・ Protein Information Resource ・ Protein inhibitor of activated STAT ・ Protein inhibitor of activated STAT2 ・ Protein isoform ・ Protein K ・ Protein K (gene expression) ・ Protein K (porin) ・ Protein kinase ・ Protein kinase A ・ Protein kinase B ・ Protein kinase C ・ Protein kinase C zeta type ・ Protein kinase D1 ・ Protein kinase domain ・ Protein kinase inhibitor ・ Protein kinase N1 ・ Protein kinase R ・ Protein kinase, AMP-activated, alpha 1 ・ Protein L ・ Protein ligand ・ Protein Local Optimization Program ・ Protein losing enteropathy ・ Protein M ・ Protein mass spectrometry ・ Protein metabolism Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Protein kinase C ： ウィキペディア英語版 Protein kinase C Protein kinase C also known as PKC (EC 2.7.11.13) is a family of protein kinase enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins. PKC enzymes in turn are activated by signals such as increases in the concentration of diacylglycerol (DAG) or calcium ions (Ca2+).〔Wilson, C.H., Ali, E.S., Scrimgeour, N., Martin, A.M., Hua, J., Tallis, G.A., Rychkov, G.Y., and Barritt, G.J. (2015). Steatosis inhibits liver cell store-operated Ca(2)(+) entry and reduces ER Ca(2)(+) through a protein kinase C-dependent mechanism. Biochem J 466, 379-390. http://www.ncbi.nlm.nih.gov/pubmed/?term=Eunus+S+Ali〕 Hence PKC enzymes play important roles in several signal transduction cascades. The PKC family consists of fifteen isozymes in humans. They are divided into three subfamilies, based on their second messenger requirements: conventional (or classical), novel, and atypical. Conventional (c)PKCs contain the isoforms α, βI, βII, and γ. These require Ca2+, DAG, and a phospholipid such as phosphatidylserine for activation. Novel (n)PKCs include the δ, ε, η, and θ isoforms, and require DAG, but do not require Ca2+ for activation. Thus, conventional and novel PKCs are activated through the same signal transduction pathway as phospholipase C. On the other hand, atypical (a)PKCs (including protein kinase Mζ and ι / λ isoforms) require neither Ca2+ nor diacylglycerol for activation. The term "protein kinase C" usually refers to the entire family of isoforms. ==Isozymes== *conventional - require DAG, Ca2+, and phospholipid for activation * * PKC-α () * * PKC-β1 () * * PKC-β2 () * * PKC-γ () * novel - require DAG but not Ca2+ for activation * * PKC-δ () * * PKC-δ1 () * * PKC-δ2 () * * PKC-δ3 () * * PKC-ε () * * PKC-η () * * PKC-θ () * atypical - require neither Ca2+ nor DAG for activation (require phosphatidyl serine) * * PKC-ι () * * PKC-ζ () * * PK-N1 () * * PK-N2 () * * PK-N3 () 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Protein kinase C」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.